Keeb kwm ntawm kev phais tuaj yeem taug qab mus rau lub hnub nyoog Neolithic nyob deb. Nrog rau kev hloov pauv ntawm lub sijhawm, kev phais tau tsim sai heev, uas ua rau muaj kev txhawb nqa kev txhim kho aseptic thiab txoj kev ua kom tsis muaj menyuam. Nyob rau hauv lub xyoo pua 19th, tshuaj loog tau yug los, thiab thawj zaug kev phais nyob rau hauv tshuaj loog tau ua nyob rau hauv 1846 los ntawm ib tug kws kho hniav Asmeskas. Txawm hais tias tus txheej txheem tau tshwm sim hauv chav tsev qiv ntawv, thiab tsis muaj leej twg hnav lub tsho dawb, qhov no tau cim qhov pib ntawm chav ua haujlwm keeb kwm. Lub Evolution ntawm Chav Ua Haujlwm: Thawj tiam ntawm chav ua haujlwm yog hu ua Genesis Simple Operating Room. Raws li cov tshuaj tau nce zuj zus, xyoo 1886, kev txhim kho ntawm cov kab mob bacteriology thiab kev tsim ua kom tsis muaj menyuam; xyoo 1887, txoj kev ntxuav tes thaum phais raug tsim; xyoo 1897, lub qhov ncauj qhov ntswg tau pib siv thaum phais; thiab xyoo 1898, cov ris tsho phais tau pib siv-tag nrho cov hnub nyoog tshaj 100 xyoo.
Nyob rau xyoo 20th-Tebchaws Europe, cov tsev kho mob tau pib muaj chav ua haujlwm sib cais hauv lawv pawg ntseeg ntau yam, cim qhov pib ntawm chav ua haujlwm thib ob, uas peb hu ua Pavilion Type. Xyoo 1937, Paris Ntiaj Teb Kev Ncaj Ncees tau tuav, thiab chav ua haujlwm niaj hnub tau tsim tsa lub sijhawm ntawd.
Hauv nruab nrab xyoo pua 20th, cov tsev kho mob hauv tsev kho mob tau pib ua haujlwm hauv nruab nrab, thiab chav ua haujlwm tau nkag mus rau hauv lawv lub sijhawm thib peb: Chav Ua Haujlwm Central (OPR). Xyoo 1955, Lub Tsev Haujlwm Saib Xyuas Kev Ua Haujlwm Central ntawm University of Tokyo tau qhib, kos npe rau qhov pib ntawm cov chav haujlwm nruab nrab hauv Nyij Pooj; nyob rau hauv 1963, lub hauv paus muab chav ua hauj lwm layout tsim nyob rau hauv lub tebchaws United States; xyoo 1966, lub ntiaj teb thawj laminar ntws huv chav ua haujlwm tau tsim los ntawm Barton Memorial Tsev Kho Mob hauv Tebchaws Meskas; thiab nyob rau hauv 1969, chav khiav hauj lwm layout pom zoo los ntawm British Department of Health yog tus qauv ntawm cov khoom siv dav siv cov khoom siv khib nyiab.